Immortality: With a Lifetime Guarantee

Immortality:
With a Lifetime Guarantee

Survival is our final ambition as a species and the only way to survive is to ensure that we are a good fit in our environment. There are two ways to survive as a species. One is to produce an enormous number of offspring and hope that a few survive long enough to pass on their genes. Another approach—one that humans are following—involves having a few children whom we nurture for more than 18 years. Nurturing is an important—and integral—component of our survival strategy. Nurturing involves having things to teach and living long enough to be able to teach them. This involves having a larger brain and longer life—and the two go together. Aging is not a dustbin of genetics, but an integral part of our strategy for survival as a species. With aging also comes the opportunity to learn about the environment. We learn in terms of our skills and also through our biology. As we age we pick-up new genetic material, modify existing genes, and fine-tune them before we pass our genes on to our children. Our lives are devoted to just this aim, except we remain ignorant of this fact for good reason. We create a model of reality in our brain. For us to engage in the world we have to be at the center and we have to believe that we are unique and have a free will. Our impression of reality, dictated by having a world that is just, fair and constant, also requires that we do not think about our own death or our model of the world becomes untenable. This is where our belief in immortality comes in. We want things to stay constant so that we can retain some level of control. Anticipating our death destroys this impression that the world is orderly and just. But there is one problem with this made-up reality, we do eventually get old, frail and die. We point at aging as the culprit. Aging is the problem that we need to solve rather than a survival strategy.  But if we understand aging we will understand the tricks of our psychology. By looking across ecological biology, genetics, biology and anthropology we can form an understanding of how aging came about as a positive attribute. With aging came a whole new dimension of human development. A life-long symphony is playing, that has a beginning, a middle and an end.  It is not just about tweaking genetics, or taking supplements, or curing aging. Our aging is an integral part of our environment and our history. We are meant to die, as much as it is detrimental to the individual, aging and death form our strategy as a species. Our personal salvation is that we delude ourselves this reality.

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The Coming Pandemic of Lyme Dementia

There are many known causes of dementia. One of these causes are bacteria. Bacteria are usually ignored despite its historical and current significance in dementia research.  A hundred years ago it was well known that syphilis—a bacterium—was the only known cause of dementia. The bacteria interferes with the nerves until it reaches the brain where it destroys the brain from the inside. In the end, the expression of long-term syphilis is dementia—Neurosyphilis. Alois Alzheimer wrote his post-doctoral thesis (Habilitationsschrift) entitled “Histological studies on the differential diagnosis of progressive paralysis.” on neurosyphilis before his supervisor Emil Kraepelin propelled him into the history books by defining Alzheimer’s disease as a new disease in 1911. [1]

Neurosyphilis was very common in the 1900s. Between one in four to one in ten people in mental institutions were there because of neurosyphilis. Eventually syphilis kills its victims. Before the introduction of penicillin in 1943, syphilis was a common killer. In 1929, among men, the death rate from syphilis was 28.3 per 100,000 for Whites and 97.9 per 100,000 for Blacks [2]. The similarities between syphilis and dementia were addressed repeatedly in the early literature in Alzheimer’s disease [1]. Because syphilis can now be treated easily and cheaply, it has nearly been eradicated. But there is a new bacterium threat emerging—one that can also cause dementia.

Today, the main bacterial threat to acquiring dementia comes from Lyme disease—a bacterium borrelia burgdorferi. Lyme disease is transmitted to humans through the bite of infected blacklegged tick. These ticks are themselves infected by feeding off diseased insects and birds, which bring the infection from across the globe. Worldwide there are 23 different species of these Lyme disease-carrying ticks.

Lyme disease is the most common disease transmitted by animals in the northern hemisphere and it is becoming an increasingly public health concern [3]. Not only because Lyme disease is a debilitating disease, but because eventually Lyme disease has been shown to cause dementia—Lyme dementia [4]. Science has not identified the mechanism for the development of Lyme dementia. The American psychiatrist  Robert Bransfield has been documenting some of its neurological expressions, but so far there is a lack of emphasis in the research community on exploring these clinical features. There is great resistance by the U.S. Center for Disease Control and Prevention (CDC) to acknowledge the importance of this infection.

Ernie Murakami, a retired physician, has been monitoring the spread of Lyme disease across the world. With more than 65 countries that have the blacklegged ticks which transmit Lyme disease. This is a worldwide pandemic.The prevalence of Lyme disease reporting varies dramatically, primarily we are not looking for it.  Canada reporting the lowest cases in the world, with 1 case per million, while Slovenia reports 13 cases per 10,000. In the United Sates the CDC reports that more than 329,000 people are likely to be infected every year in the U.S. alone. Only one in ten cases are reported since clinicians are not looking for Lyme disease. This estimated number of annual infections is higher than hepatitis C, HIV, colon cancer, and breast cancer. Lyme disease accounts for more than 90% of all reported cases of diseases transmitted by animals (vector-borne illness).

With any good public health strategy there needs to be a two pronged response--prevention and control: addressing the clinical effects of the disease and the underlying cause. In the United States, although there are minimal research funds to examine and explore cures for Lyme disease, this avenue is likely to see the most significant increase in funding. But this would be folly without addressing the underlying cause of the disease. Addressing these underlying causes will however be challenging.

Harvard Medical School Center reports that areas suitable for tick habitation will quadruple by the 2080s. But there are more pressing changes that will happen in our lifetime. Deforestation and climate-induced habitat change are affecting insect which carry diseases like malaria and Lyme disease. Slow climate change, urban growth in areas next to forests, reforestation following the abandonment of agriculture, and increases in the deer, mice and squirrel populations (among many others) which harbor these ticks.

Malaria and Lyme disease are both projected to increase. Even taking a more conservative estimate (all of the USA, most of Canada, all of Europe, Middle East and China), more than half the world’s populations are exposed to Lyme disease. A proportion of these populations will become infected with Lyme disease and eventually some will develop dementia. Pure Lyme dementia exists and reacts well to antibiotics [4].  Is public health ready to address this?

© USA Copyrighted 2017 Mario D. Garrett 

References:

[1] Garrett MD (2015) Politics of Anguish: How Alzheimer's disease became the malady of the 21st century. Createspace. USA.

[2] Hazen H.H. (1937). A leading cause of death among Negroes: Syphilis. Journal of Negro Education, 310-321.

[3] Pearson S. (2014). Recognising and understanding Lyme disease. Nursing Standard, 29(1): 37-43.

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[4] Blanc F., Philippi N., Cretin B., Kleitz C., Berly L., Jung B., ... & de Seze J. (2014). Lyme Neuroborreliosis and Dementia. Journal of Alzheimer's Disease, 41(4): 1087-93.