Sunday, May 17, 2015

Fluoride Levels and Falls Among Elderly


In May 2015, the U.S. Centers for Disease Control and Prevention (CDC) released its mortality report showing that the only increase in unintentional injury that lead to mortality was due to falls among older adults.  While all other causes of mortality remained fairly stable, between 2000 and 2013, death from falls in older adults nearly doubled, from 30 to 57 deaths per 100,000 older adults.  In any given year, one in three older adults will have a fall and 20-30% of these victims will suffer a moderate or severe injury. A quarter will die before the year is over. This is a public health tragedy.
Men are 40% more likely than women to die from a fall. While older Whites are 2.7 times more likely to die from falls as their Black counterparts.

Falls are the most common cause of traumatic brain injuries (TBI).5
Half of all fatality because of falls  are due to TBI.7

The most common injuries when older fall are fractures to spine, hip, forearm, leg, ankle, pelvis, upper arm, and hand.  Of these, the most serious is hip fracture. In a large number of cases leading to death. In contradiction, although falls remains on the increase from 1996 to 2010, hip fracture rates declined significantly for men and women (13). Over 95% of hip fractures are caused by falls. It is not known what factors are contributing to this trend. This seemingly contradictory evidence

A woman's bone density declines by about 30% between the ages of 50 and 80 increasing 5 years after menopause. Although bone density is not the only factor in hip fracture risk. Over 90% of hip fractures occur upon falling. Although many elderly people suffer spontaneous hip fractures because of advanced osteoporosis, the immediate cause is a fall. But this information is not validated. If a fall was instigated by a spontaneous hip fracture, the older adult is more likely to find an "excuse" for the fall rather than accept (and understand the mechanics) or a spontaneous fracture. There are distinct breaks if it is due to a fall or due to a spontaneous hip fracture.


Falls can be complex, and the literature has numerous causal pathways--from increased medication, older and frailer adults, better reporting, better health surveillance,  heavier older adults--all of which are valid. But there is one cause that is not mentioned.

Most researchers assume that an older adult fall and then break their hip. Or if they fall, they try and find behavioral reasons for the fall.  However it is also likely that there is a spontaneous hip fracture which causes the older adult to fall. There is a spontaneous hip fracture and then the person falls. Such fracture can easily be determined. As yet CDC has not undertaken this study. It would be relatively easy to review the X-rays from those that died. This study would not even need an Institutional Review Board. But until that study is done we can only conjecture the cause of these hip fractures.

It could be that there is an environmental cause to the increase in fractures related to state policies that the Federal agency supports: fluoridation of our water. There is overwhelming evidence that fluoridation in our water is toxic. Although the topical application of fluoride on teeth has been found to be beneficial, the ingestion of fluoride continues to receive negative outcomes. The argument that it improves dental health becomes less realistic when more than a quarter of adults over the age of 60 have dentures. The fact that this policy of water fluoridation ignored older adult health is already established. What is being established now is that it is harmful to older adults.

One of the reasons why falls are on the increase is because the bones of older adults in the U.S. are being made brittle because of fluoridation of water and that these spontaneous fractures are causing some or most of the falls. Multiple studies support this assertion: Fluoride therapy may be implicated in the pathogenesis of hip fractures which may occur in treated patients despite a rapid, marked increase in bone mass. (6)  Fluoride appears to be a key factor in the pathogenesis of stress fractures (7) [T]he six hip fractures occurring in patients receiving fluoride during 72.3 patient years of treatment is 10 times higher than would be expected in normal women of the same age (8) Thirteen cases of spontaneous fissure or fracture of the lower limbs observed in 8 patients under treatment with sodium fluoride are reported (9). (Fluoridation)...to worsen a patient’s clinical state (1) Increasing the dose of fluoride increases the risk of nonvertebral fractures  (2) 1 year of fluoride administration seemed to reduce bone strength by 17-30% (3) patients treated with sodium fluoride,...All fractures were spontaneous in onset... three times that in untreated osteoporosis. (4) Fluoride treatment was “associated with a significant three-fold increase in the incidence of nonvertebral fractures (5) fluoride-induced microfractures (10)
sustained spontaneous bilateral hip fractures during treatment with fluoride, calcium, and vitamin D for osteoporosis (11) Three or four of the fractures in the fluoride group appeared to be spontaneous hip fractures...the fluoride treatment here was probably partly responsible for the fractures in our cases. (12)
CDC needs to review the X-rays of all older adults that die due to falls. Ascertain the level of spontaneous hip fractures. Examine the correlation with fluoridation in the public water system. Measure the accumulation of fluoride in older adults. Engage in a systematic review of fluoridation on older adult comprehensive health including skeletal, digestive system and neurological.

  • There is no correlation among countries that fluoridate their water and hip fractures. 
    In 2002 in an international comparative study John Kanis from the WHO Collaborating Center for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, United Kingdom and his colleagues reported some dramatic variance in hip fracture incidence from different regions of the world. Lifetime risk at the age of 50 years varied from 1% in women from Turkey to 28.5% in women from Sweden. The risk for women was correlated with that for men. Countries were categorized by 10-year probabilities comprising very high risk (Norway, Iceland, Sweden, Denmark, and the United States), high risk (Taiwan, Germany, Switzerland, Finland, Greece, Canada, The Netherlands, Hungary, Singapore, Italy, United Kingdom, Kuwait, Australia, and Portugal), medium risk (Hong Kong, France, Japan, Spain, Argentina, and China), and low risk (Turkey, Korea, Venezuela, and Chile). Only 6 OECD countries have more than 50% of their populations drinking fluoridated water: Australia (80%), Chile (70%), the Irish Republic (73%), Israel (70%), New Zealand (61%), and the United States (64%).

1. Gutteridge DH, et al. (2002). A randomized trial of sodium fluoride (60 mg) +/- estrogen in postmenopausal osteoporotic vertebral fractures: increased vertebral fractures and peripheral bone loss with sodium fluoride; concurrent estrogen prevents peripheral loss, but not vertebral fractures. Osteoporosis International 13:158-70.

2. Haguenauer D, et al. (2000). Fluoride for the treatment of postmenopausal osteoporotic fractures: a meta-analysis. Osteoporosis International 11:727-38.

3 Sogaard CH, et al. (1994). Marked decrease in trabecular bone quality after five years of sodium fluoride therapy–assessed by biomechanical testing of iliac crest bone biopsies in osteoporotic patients. Bone 15: 393-99.

4. Schnitzler CM, et al. (1990). Bone fragility of the peripheral skeleton during fluoride therapy for osteoporosis. Clinical Orthopedics (261):268-75.

5. Riggs BL, et al. (1990). Effect of Fluoride treatment on the Fracture Rates in Postmenopausal Women with Osteoporosis. New England Journal of Medicine 322:802-809.

6. Bayley TA, et al. (1990). Fluoride-induced fractures: relation to osteogenic effect. Journal of Bone and Mineral Research 5(Suppl 1):S217-22.

7. Orcel P, et al. (1990). Stress fractures of the lower limbs in osteoporotic patients treated with fluoride. Journal of Bone and Mineral Research 5(Suppl 1): S191-4.

8. Hedlund LR, Gallagher JC. (1989). Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride. Journal of Bone and Mineral Research 2:223-5.

9. Orcel P, et al. (1987). [Spontaneous fissures and fractures of the legs in patients with osteoporosis treated with sodium fluoride]. Presse Med 16:571-5.


10. Dambacher MA, et al. (1986). Long-term fluoride therapy of postmenopausal osteoporosis. Bone 7: 199-205.

11. Gerster JC, et al. (1983). Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis. British Medical Journal (Clin Res Ed). 287(6394):723-5.


12.  Inkovaara J, et al. (1975). Phophylactic fluoride treatment and aged bones. British Medical Journal 3: 73-74.

13. Stevens JA, Rudd RA. The impact of decreasing U.S. hip fracture rates on future hip fracture estimates. Osteoporosis International 2013. DOI 10.1007/s00198-013-2375-9.

Monday, May 4, 2015

Geography of Aging and the Illusion of Self

I think of myself as an entity, as "me."  Separate and distinct from "them" and the outside world. This "me" allows my mind to cleverly edit, interpret and re-interpret the world as though I am consistently at the center of everything that I interact with.  My mind also draws a linear story-line from my childhood directly to my older-adulthood.  I do not have to think about it because my mind automatically narrates a story for me that is complete where I am at the center and the rest is on the periphery. A story of "me" and "them", a logical relationship. I have an explanation for everything even though most events in my life are outside of my control.  This gives me the impression that I am "me", separate, distinct and unique, and then there is a "them" an outside. I have conscious will and participate in the world as a free unique and independent agent.

But this belief is a mirage, an illusion of the mind. The idea that we are separate from others is not the complete picture, and this knowledge is just now starting to be exposed. To re-envisioning who we are we have to understand how the "me" came about. This is a radical idea. Such radical ideas have happened before in our collective history and they have changed how we think about who we are.

There have been a number of radical thinkers who transformed how we think of ourselves.  The first such radical thinker moved us away from mythology, and the notion that everything that happens is because "god wants it to happen." Thales of Miletus was a 6th century BC  philosopher who suggested that we should observe physical events without assigning the cause to "god." He admonished philosophers to try and understand what they observe as separate from god. This was the birth of science. As a result we began to understand that there is a causal pattern to the world. That there is a logical sequence that does not require the intervention of busy gods. The development of science took us into an amazing logical world that was hidden to us before. We came to see the world in more detail. As a finely tuned mechanical watch. This assurance of solidity was however shattered in the early 1900s on two fronts. The first to dispel the solidity of how we see our world was Sigmund Freud. Freud developed the concept of an unconscious mind that hid psychological energies from us such as the Oedipus complex, libido and death drive among others. Freud's main contribution was the acceptance that we do not know "us", that we have a reality that is hidden from us.  What Freud did for psychology, Albert Einstein did for our concept of outside reality. Einstein, a theoretical physicist, developed a general theory of relativity which together with quantum mechanics and the law of the photoelectric effect evolved into quantum theory. Einstein transformed Newtonian mechanicswhere object were treated as physical representation but much smallerto one where at great microscopic details these realities changed into energy and shivering mass. He conceived of the world as composed of waves of energy,  a vibrating nexus of excited mass. These ideas later flourished into an idea of reality as a probability of energy waves. Completely transforming how we look at the universe we believed to be solid.

These ideas came from a culmination of prior small developments that helped Thales, Freud and Einstein make a conceptual leap. We are now ready for another leap. Another way of looking at ourselves...again.

It started when scientists started finding that conscious thought is a product of an unconscious process. We are "aware" because there is an earlier process that we are not aware of that wants us to be aware. The late Benjamin Libet from UCSF was a pioneer in showing that a conscious decision can be monitored neurologically sometimes as much as ten seconds before the activity appearswhich he termed readiness potential. In effect, by monitoring the brain's EEG we can predict rudimentary activity before people become conscious of itsuch as moving your index finger. More recently, Itzak Fried from UCLA recorded single neurons and found that the readiness potential isn't a diffuse state of readiness, but is a very specific set of instructions. Our consciousness was an after thought to a specific decision that has already been taken.  This resulted in what Daniel Wegner called in his 2002 book "The Illusion of Conscious Will." It is an illusion that we cannot dispel, despite knowing that it is an illusion, because it is how we think. We think that we have conscious will.

If there is no conscious will, then it brings into question the validity of the division of self/mind and brain/body that RenĂ© Descartes defined in the 1600s. This Cartesian Dualism has constrained our thinking for more than four centuries. This belief is that there is a separation of the mind from the body and that the self is not defined by the mind but something higher. But this is proving to be wrong. But more important than thisalthough for academics this is really importantis that if our consciousness is part of a pre-determined process, then what other realities are there that we are not aware of? If there is no such thing as a self/mind and brain/body division, then what is there?  I think of "me" as the product of a coherent sequential story that lead me here as a sentient being in a determined place, undertaking a conscious activity. I feel responsible for where I am and what I am doing. Which is why nationalism is so strong even though where we are born is a random event. Most people take ownership of their situation.

Because our brain is so vast in its complexity it is able to create a representation of the world. It uses this model to predict. That is how we survive and flourish. Prediction is also the basis for all scientific theory. My brain builds a virtual reality and interacts within this model. Very much like a computer game where I "am" the avatar. And very much like the avatar, my mind makes me unique, distinct and sequential being with a history that I own. Our reality is a creative process. We create this reality. We negotiate with our body and our mind about how to tell this story of reality. On one side is the concept of "me" and on the other the story of "others." The reality is that there is a place where there is no distinction. Our body holds that special place. It is both part of the environment and part "me". The illusion is the "me."  This is especially true of routines of everyday lifethose activities and customary habits that are expected and anticipated. Routines are patterns of behavior that we build over time and internalized. We are unaware of these habits of behaving. And it is not just that we are unconscious of them but that our body has adapted without making us aware, and we know about these changes because we can measure them.

Stress chemicals in the bodysuch as the allostatic load and IL-6is higher in people that live in communities with greater densities of poor older adults and in racially segregated communities. This relationship was found to be independent of important individual level risk factors (e.g. smoking or obesity). A stressful environment—such a poor neighborhood—results in negative changes in the chemical composition in our bodies. These chemical states initiate other changes. Changing chemical composition in our bodies have lasting effects because they switch the expression of some genes. These epi-genes can be switched on and off, establishing a consistent optimum level of chemical balance within the body. Environmental factors such as mercury in water, second-hand smoke, diet including foliate, pharmaceuticals, pesticides, air pollutants, industrial chemicals, heavy metals, hormones in water, nutrition, and behavior have been shown to affect epi-genetics.  Furthermore, epi-genetic changes are associated with specific outcomes such as cancer, diabetes, obesity, infertility, respiratory diseases, allergies, and neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. Our body changes our epi-geneswhich establishes an optimum level of chemical balance in response to our environment. Richard Rorty in 1979 said this beautifully “So the paradoxical conclusion offered earlierthat had physiology been more obvious psychology would never have arisencan be reaffirmed. Indeed, we can strengthen it and say that if the body had been easier to understand, nobody would have thought that we had a mind.” (p 239).

Who we are is not who we think we are. Thales, Freud and Einstein have shown us how our perception is incomplete. The next frontier is the idea of self. Our body has a memory that we are unaware of. There is a reality in our body that reflects the geography of our communities, including people that we interact with on a consistent basis. This is necessarily unconscious since the body is complex. Our consciousness is an afterthought of decisions already taken in order to provide the illusion of active participants, an avatar. It provides us with the illusion of "me". But it is an illusion.  The reality is that there is no "me" but a place of interaction. A place where the illusion of a unique "me" interacts with the outside world, the geography the community and significant others.Who I am is not who I think I am. And we feel this reality sometimes as a spiritual existence. Something that extends human identity beyond the self. Learning compassion, empathy and love is when we truly become one with this reality. Try and translate love without referring to a world where their is a union of beings, of community of geographies. All religions start from this understanding, but the way that our mind worksneeding to create separateness and pushing us into an egocentric world viewcorrupts this initial insight and re-interprets it as "them" and "us." But what we are learning is that there is a union of those around us and the geography that we live in. Our identify of self is an afterthought.

The body and the mind  have already determined its strategy for existence. And if I accept that there is not just a "me" but also a "we" inside my body then I can understand how my environment, my community, family and friends can determine my behavior and outcomes, as much as I think I do myself. My interaction with the world leaves evidence in my genes just as I leave traces in my world.

The symbiotic relationship exposes humans to a greater sense of belonging within their geography since we carry our geography within us in our bodies. If we are going to understand how extreme-longevity occurs we need to understand this construct much better than we do today. And perhaps our understanding of why happy people, people that volunteer, people that are religious, people that are in love, live longer should not be seen as a strategy but as an expression of people that are in touch with this reality of who they truly are...a union of their geography and their community.

© USA Copyrighted 2015 Mario D. Garrett

Further Reading:

Libet, B. (1985). "Unconscious Cerebral Initiative and the Role of Conscious Will in Voluntary Action". The Behavioral and Brain Sciences 8: 529–566. doi:10.1017/s0140525x00044903.

Wegner, D. M. (2002). The illusion of conscious will. MIT press.

Garrett M. D. (2014) Geograph of Elderly. Oxford Bibliography.
Online: http://www.oxfordbibliographies.com/view/document/obo-9780199874002/obo-9780199874002-0062.xml